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Pharmacol Rep. 2016 Dec;68(6):1120-1125. doi: 10.1016/j.pharep.2016.06.016. Epub 2016 Jul 1.

The usefulness of monitored therapy using Clozapine concentration in the blood serum for determining drug dose in Polish schizophrenic patients.

Author information

1
Department of Biochemistry and Clinical Chemistry, Medical University, Warszawa, Poland.
2
Department of Psychiatry, Medical University, Warszawa, Poland. Electronic address: maria.radziwon@wum.edu.pl.
3
Department of Psychiatry, Medical University, Warszawa, Poland.
4
Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Smętna street 12, Poland.

Abstract

BACKGROUND:

The aim of the study is to evaluate the advisability of systematic monitoring of clozapine (CLO) concentration in serum during treatment of schizophrenia in Polish psychiatric patients.

METHOD:

The concentration of CLO and its metabolites: norclozapine (NCLO) and clozapine N-oxide (CLO-NO) in serum obtained from 107 patients suffering from schizophrenia was determined by high performance liquid chromatography (HPLC) method. There were two groups of patients. In the first group of patients (n=95) the concentration of drug and its metabolites was determined by one-time testing. Correlations were tested using the test statistics. In the second group of patients (n=12), 51 samples of serum were provided by the same patient in different time spans (from 6days to 14 months after the beginning of the treatment).

RESULTS:

Concentrations of CLO and its metabolites in blood serum do not always show a linear dependence on the applied dose for individual patients.

CONCLUSION:

The high volatility of CLO concentrations in blood serum of patients treated with identical doses of the drug confirmed the validity of the monitored therapy.

KEYWORDS:

Clozapine; Clozapine N-oxide; Norclozapine; Schizophrenia; Therapeutic drug monitoring

PMID:
27588387
DOI:
10.1016/j.pharep.2016.06.016
[Indexed for MEDLINE]

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