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J Biomed Opt. 2016 Sep 1;21(9):95001. doi: 10.1117/1.JBO.21.9.095001.

Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis.

Author information

1
Indian Institute of Technology (Indian School of Mines) Dhanbad, Department of Applied Physics, Academic Complex, Dhanbad, Jharkhand 826004, IndiabUniversity of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, Urbana, Illinois 61801, United StatescUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, 619 South Wright Street, Champaign, Illinois 61820, United States.
2
University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, Urbana, Illinois 61801, United StatescUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, 619 South Wright Street, Champaign, Illinois 61820, United States.
3
University of Illinois at Urbana-Champaign, Department of Kinesiology and Community Health, 906 South Goodwin Avenue, Urbana, Illinois 61801, United States.
4
University of Illinois at Urbana-Champaign, Department of Kinesiology and Community Health, 906 South Goodwin Avenue, Urbana, Illinois 61801, United StateseUniversity of Alabama at Birmingham, Department of Physical Therapy, 1720 2nd Avenue South, Birmingham, Alabama 35294, United States.
5
University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, Urbana, Illinois 61801, United StatescUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, 619 South Wright Street, Champaign, Illinois 61820, United StatesfUniversity of Illinois at Urbana-Champaign, Department of Bioengineering, 1304 West Springfield Avenue, Urbana, Illinois 61801, United StatesgUniversity of Illinois at Urbana-Champaign, Department of Internal Medicine, 506 South Mathews Avenue, Urbana, Illinois 61801, United States.

Abstract

We performed ratiometric analysis of retinal optical coherence tomography images for the first time in multiple sclerosis (MS) patients. The ratiometric analysis identified differences in several retinal layer thickness ratios in the cohort of MS subjects without a history of optic neuritis (ON) compared to healthy control (HC) subjects, and there was no difference in standard retinal nerve fiber layer thickness (RNFLT). The difference in such ratios between HC subjects and those with mild MS-disability, without a difference in RNFLT, further suggests the possibility of using layer ratiometric analysis for detecting early retinal changes in MS. Ratiometric analysis may be useful and potentially more sensitive for detecting disease changes in MS.

PMID:
27588382
PMCID:
PMC5996866
DOI:
10.1117/1.JBO.21.9.095001
[Indexed for MEDLINE]
Free PMC Article

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