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Mod Rheumatol. 2017 Jul;27(4):669-674. doi: 10.1080/14397595.2016.1230296. Epub 2016 Sep 20.

Associations of dietary and serum magnesium with serum high-sensitivity C-reactive protein in early radiographic knee osteoarthritis patients.

Author information

1
a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
2
b Health Management Center , Xiangya Hospital, Central South University , Changsha , China , and.
3
c Department of Epidemiology and Health Statistics, School of Public Health , Central South University , Changsha , China.

Abstract

INTRODUCTION:

This study aimed to examine the associations of dietary magnesium (Mg) intake and serum Mg concentration with the high-sensitivity C-reactive protein (hsCRP) level in early radiographic knee osteoarthritis (OA) patients.

METHODS:

Multivariable logistic regression was used to test the associations of dietary and serum Mg with the serum hsCRP in early radiographic knee OA patients after adjustment of a number of potential confounding factors.

RESULTS:

A total of 936 early radiographic knee OA patients were included. A significant association between dietary Mg intake and hsCRP was observed. The multivariable-adjusted odds ratio (OR) (95% CI) for elevated hsCRP (≥3.0 mg/l) in the second, third, fourth, and fifth dietary Mg intake quintile were 0.44 (95% CI: 0.24-0.82), 0.58 (95% CI: 0.31-1.10), 0.34 (95% CI: 0.15-0.77), and 0.19 (95% CI: 0.06-0.57), respectively, compared with the lowest (first) quintile, and p for trend was 0.01. A significant association between serum Mg concentration and hsCRP was observed. The multivariable-adjusted OR (95% CI) for elevated hsCRP in the second, third, fourth, and fifth serum Mg concentration quintile were 0.63 (95% CI: 0.35-1.12), 0.83 (95% CI: 0.50-1.39), 0.53 (95% CI: 0.31-0.91), and 0.46 (95% CI: 0.25-0.85), respectively, compared with the lowest quintile, and p for trend was 0.01.

CONCLUSION:

The present study indicated that both dietary and serum Mg were inversely associated with serum hsCRP in early radiographic knee OA patients.

KEYWORDS:

High-sensitivity C-reactive protein; Magnesium; Osteoarthritis

PMID:
27588353
DOI:
10.1080/14397595.2016.1230296
[Indexed for MEDLINE]

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