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Respir Care. 2016 Sep;61(9):1217-23. doi: 10.4187/respcare.04590.

Reference Values for the Diffusing Capacity Determined by the Single-Breath Technique at Different Altitudes: The Latin American Single-Breath Diffusing Capacity Reference Project.

Author information

1
Departamento de Fisiología Respiratoria. Instituto Nacional de Enfermedades Respiratorias, "Ismael Cosío Villegas," Tlalpan, Distrito Federal, Mexico. drjcvazquez@gmail.com.
2
Departamento de Fisiología Respiratoria. Instituto Nacional de Enfermedades Respiratorias, "Ismael Cosío Villegas," Tlalpan, Distrito Federal, Mexico.
3
Fundación Neumológica Colombiana, Bogotá, Colombia.
4
Instituto Nacional del Tórax y Universidad de Chile, Santiago de Chile, Chile.
5
Universidad Central de Venezuela, Caracas, Venezuela.

Abstract

BACKGROUND:

The lung diffusion capacity (DLCO) determined by the single-breath technique greatly helps in the differential diagnosis and classification of severity of common lung diseases. However, widespread use of single-breath DLCO tests in Latin America has been limited, in part, by the lack of appropriate reference values. Our objective was to derive robust reference equations for single-breath DLCO from healthy Hispanic adults, using the most recent guidelines and taking into account altitude above sea level and hemoglobin.

METHODS:

We recruited healthy adults from Caracas (690 m), Santiago (650 m), Mexico City (2,240 m), and Bogota (2,640 m). DLCO testing was completed using an instrument that exceeds American Thoracic Society/European Respiratory Society 2005 guidelines for spirometry and single-breath DLCO and provided centralized training and a quality assurance program.

RESULTS:

We included 480 healthy Hispanic adults (58.3% women) with a mean age of 46 y (range 22-83 y). Their mean ± SD single-breath DLCO was 30.4 ± 9.2 mL/min/mm Hg. Results as a percentage of predicted by Crapo's reference values (the closest to obtained values) were 83 ± 10% (Caracas), 91 ± 10% (Santiago), 104 ± 17% (Mexico City), and 118 ± 19% (Bogota), and current suggested adjustments by hemoglobin or altitude did not correct differences, especially in Santiago and Caracas.

CONCLUSIONS:

We recommend these new single-breath DLCO reference equations to predict single-breath DLCO in Latin America performed with current instruments and procedures and including as a predictor altitude above sea level.

KEYWORDS:

DLCO; altitude; hemoglobin; reference values

PMID:
27587868
DOI:
10.4187/respcare.04590
[Indexed for MEDLINE]
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