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Genome Announc. 2016 Sep 1;4(5). pii: e00883-16. doi: 10.1128/genomeA.00883-16.

High-Quality Genome Assembly and Annotation for Plasmodium coatneyi, Generated Using Single-Molecule Real-Time PacBio Technology.

Author information

1
International Center for Malaria Research, Education and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA Malaria Host-Pathogen Interaction Center, Emory University, Atlanta, Georgia, USA.
2
Department of Genetics, Institute of Bioinformatics, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA Malaria Host-Pathogen Interaction Center, Emory University, Atlanta, Georgia, USA.
3
Biosystems Informatics & Genomics, René Rachou Research Center (CPqRR-FIOCRUZ), Belo Horizonte, Minas Gerais, Brazil.
4
Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Malaria Host-Pathogen Interaction Center, Emory University, Atlanta, Georgia, USA.
5
International Center for Malaria Research, Education and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA Malaria Host-Pathogen Interaction Center, Emory University, Atlanta, Georgia, USA mgalins@emory.edu.

Abstract

Plasmodium coatneyi is a protozoan parasite species that causes simian malaria and is an excellent model for studying disease caused by the human malaria parasite, P. falciparum Here we report the complete (nontelomeric) genome sequence of P. coatneyi Hackeri generated by the application of only Pacific Biosciences RS II (PacBio RS II) single-molecule real-time (SMRT) high-resolution sequence technology and assembly using the Hierarchical Genome Assembly Process (HGAP). This is the first Plasmodium genome sequence reported to use only PacBio technology. This approach has proven to be superior to short-read only approaches for this species.

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