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Pituitary. 2017 Feb;20(1):84-92. doi: 10.1007/s11102-016-0748-8.

Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary.

Author information

1
Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia. lvsyro@une.net.co.
2
Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
3
Laboratorio de Patologia y Citologia Rodrigo Restrepo. Department of Pathology, Clinica Las Americas, Universidad CES, Medellin, Colombia.
4
Division of Neuro-oncology, Instituto de Cancerologia, Clinica Las Americas, Medellin, Colombia.

Abstract

INTRODUCTION:

Histologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH-releasing hormone secreting tumors or in familial pituitary tumor syndromes.

MATERIALS AND METHODS:

A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly.

RESULTS:

This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary.

CONCLUSION:

The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed.

KEYWORDS:

Acromegaly; Classification; Diagnosis; Immunohistochemistry; Pathology; Pituitary neoplasms

PMID:
27586499
DOI:
10.1007/s11102-016-0748-8
[Indexed for MEDLINE]

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