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Temperature (Austin). 2014 Jul 17;1(2):92-3. doi: 10.4161/temp.29972. eCollection 2014 Jul-Sep.

Transitioning between entry and exit from mammalian torpor: The involvement of signal transduction pathways.

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Institute of Biochemistry; Department of Biology; Carleton University; Ottawa, ON Canada.


Signal transduction pathways transmit information received at the cell surface to intracellular targets which direct a response. We highlight the involvement of signaling pathways in mediating transitions between mammalian torpor and euthermia and suggest these promote survival under stressors (e.g., hypothermia, ischemia-reperfusion) that would otherwise cause damage in nonhibernators.


arousal; entrance; mammalian hibernation; signal transduction; stress response

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