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J Int Soc Prev Community Dent. 2016 Jul-Aug;6(4):265-71. doi: 10.4103/2231-0762.186805.

Distant metastasis from oral cancer: A review and molecular biologic aspects.

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Department of Oral Pathology, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran.


Oral squamous cell carcinoma (OSCC) has been estimated to be the sixth most common cancer worldwide. The distant metastasis plays a critical role in the management and prognosis in oral cancer patients. Regarding the distant metastasis from the oral cancer, the hypopharynx is the most common primary site, followed by the base of tongue and anterior tongue. The present review article analyzes the characteristics of the distant metastases from the oral cavity from 1937 to 2015.


Incidence; metastasis; molecular biology; oral cancer

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