Format

Send to

Choose Destination
Chem Pharm Bull (Tokyo). 2016;64(9):1403-7. doi: 10.1248/cpb.c16-00355.

Practical Synthesis of Spermine, Thermospermine and Norspermine.

Author information

1
School of Pharmaceutical Sciences, University of Shizuoka.

Abstract

Polyamines, such as spermine (1), thermospermine (2) and norspermine (3), are widely distributed in nature, and have multiple biological activities. In addition, many of their conjugates have potential for pharmacological use. Here, we present a solid-phase synthesis using our nitrobenzenesulfonyl (Ns) strategy, which can provide 1, 2 and 3 on a gram scale. This approach should be suitable for facile construction of a diverse library of polyamines.

PMID:
27581645
DOI:
10.1248/cpb.c16-00355
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center