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Acta Neurol Scand. 2016 Sep;134 Suppl 200:34-8. doi: 10.1111/ane.12647.

Immunological processes related to cognitive impairment in MS.

Author information

1
Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Abstract

In this review, the immune-to-brain communication pathways are briefly summarized, with emphasis on the impact of immune cells and their mediators on learning, memory and other cognitive domains. Further, the acute response of the central nervous system to peripherally generated inflammatory stimuli - termed as sickness behaviour - is described, and the central role of microglia in this immune-to-brain crosstalk in physiological and pathological conditions is highlighted. Finally, the role and consequences of immunological processes related to cognitive impairment in multiple sclerosis are discussed.

KEYWORDS:

cognition; cognitive impairment; immunology; multiple sclerosis; sickness behaviour

PMID:
27580904
DOI:
10.1111/ane.12647
[Indexed for MEDLINE]

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