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Dis Markers. 2016;2016:9831237. doi: 10.1155/2016/9831237. Epub 2016 Aug 8.

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma.

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Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania; Department of Dermatology, "Prof. N. C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania.
Dermatology Research Laboratory, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.
Department of Plastic and Reconstructive Surgery, "Bagdasar Arseni" Clinical Emergency Hospital, 041915 Bucharest, Romania.
Department of Biochemistry, Faculty of Dental Medicine, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
Gade Laboratory for Pathology and Centre for Cancer Biomarkers (CCBio), Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway; Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway.


Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predisposed individuals, this being reflected by the anatomical distribution of lesions mainly on sun-exposed skin areas. Early diagnosis and prompt management are of crucial importance in order to prevent local tissue destruction and subsequent disfigurement. Although various noninvasive or minimal invasive techniques have demonstrated their utility in increasing diagnostic accuracy of BCC and progress has been made in its treatment options, recurrent, aggressive, and metastatic variants of BCC still pose significant challenge for the healthcare system. Analysis of gene expression and proteomic profiling of tumor cells and of tumoral microenvironment in various tissues strongly suggests that certain molecules involved in skin cancer pathogenic pathways might represent novel predictive and prognostic biomarkers in BCC.

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