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J Infect Dis. 2017 Apr 1;215(7):1080-1084. doi: 10.1093/infdis/jiw403.

Primary Polyomavirus Infection, Not Reactivation, as the Cause of Trichodysplasia Spinulosa in Immunocompromised Patients.

Author information

1
Department of Medical Microbiology, Leiden University Medical Center.
2
Departments of Dermatology.
3
Hematology.
4
Pathology, and.
5
Internal Medicine.
6
Department of Virology, University of Helsinki and Helsinki University Hospital, Finland.
7
Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands; and.
8
Medical Microbiology, University of Groningen, University Medical Center Groningen, and.

Abstract

Classic human polyomaviruses (JC and BK viruses) become pathogenic when reactivating from latency. For the rare skin disease trichodysplasia spinulosa, we show that manifestations of the causative polyomavirus (TSPyV) occur during primary infection of the immunosuppressed host. High TSPyV loads in blood and cerebrospinal fluid, sometimes coinciding with cerebral lesions and neuroendocrine symptoms, marked the acute phase of trichodysplasia spinulosa, whereas initiation and maturation of TSPyV seroresponses occurred in the convalescent phase. TSPyV genomes lacked the rearrangements typical for reactivating polyomaviruses. These findings demonstrate the clinical importance of primary infection with this rapidly expanding group of human viruses and explain the rarity of some novel polyomavirus-associated diseases.

KEYWORDS:

cidofovir; dissemination; polyomavirus; primary infection; reactivation; trichodysplasia spinulosa; viral load

PMID:
27578847
DOI:
10.1093/infdis/jiw403
[Indexed for MEDLINE]

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