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Wien Med Wochenschr. 2016 Oct;166(13-14):431-436. Epub 2016 Aug 30.

Iron, microbiota and colorectal cancer.

Author information

1
Clinical Research Fellow, Queens Medical Centre, Nottingham Digestive Disease Centre, E Floor West Block, Derby Rd, NG7 2UH, Nottingham, UK. oliver.ng@nottingham.ac.uk.

Abstract

Iron deficiency and anaemia are common in colorectal cancer. Replacement with oral or intravenous iron effectively treats this deficiency. However, mechanistic and population studies suggest that excess iron promotes colorectal carcinogenesis. Growing research into gut microbiota and dysbiosis suggests one explanation for this association. Iron is growth limiting for many pathogenic bacteria and may promote a shift in the ratio of pathogenic to protective bacteria. This may increase the toxic bacterial metabolites, promoting inflammation and carcinogenesis. This has important implications as we seek to correct anaemia in our patients.

KEYWORDS:

Anaemia; Carcinogenesis; Colorectal cancer; Dysbiosis; Iron deficiency

PMID:
27577249
DOI:
10.1007/s10354-016-0508-4
[Indexed for MEDLINE]

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