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Eur J Clin Nutr. 2017 Jan;71(1):92-96. doi: 10.1038/ejcn.2016.151. Epub 2016 Aug 31.

Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients.

Author information

1
Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran.
2
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
3
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran.
4
Department of Rheumatology, Ahwaz University of Medical Science, Ahwaz, Iran.
5
Department of Epidemiology, School of Health, Shiraz University of Medical Science, Shiraz, Iran.

Abstract

BACKGROUND/OBJECTIVES:

Since the main characteristics of Rheumatoid Arthritis (RA) are joint dysfunction caused by inflammation and serious pain, anti-inflammatory agents may alleviate the clinical symptoms in RA. Pomegranate juice is rich in polyphenolic compounds that possess antioxidant and anti-inflammatory activities. This study aimed to determine the beneficial effects of pomegranate extract (POMx) in RA patients.

SUBJECTS/METHODS:

A total of 55 RA patients were enrolled and randomly allocated to an intervention group (n=30) or a control group (n=25). The intervention group received 2 capsules of 250 mg POMx and the control group 2 capsules of 250 mg cellulose per day for 8 weeks. At the beginning of the study and after 8 weeks, Health Assessment Questionnaire (HAQ) and Disease Activity Score (DAS) 28 were completed and serum concentrations of C-reactive protein (CRP), matrix metalloproteinases 3 (MMP3), malondialdehyde (MDA), glutathione peroxidase (GPx) and erythrocyte sedimentation rate (ESR) were analyzed using standard methods and compared between the two groups.

RESULTS:

Compared with the placebo group, POMx supplement significantly reduced the score of DAS28 (P<0.001) which could be related to the decrease in swollen (P<0.001) and tender joints (P=0.001) count, pain intensity (P=0.003) and ESR levels (P= 0.03). POMx consumption also decreased HAQ score (P=0.007) and morning stiffness (P=0.04) and increased GPx concentrations (P<0.001). There were no differences in the change in mean MMP3, CRP and MDA levels between two groups.

CONCLUSIONS:

POMx alleviates disease activity and improves some blood biomarkers of inflammation and oxidative stress in RA patients.

PMID:
27577177
DOI:
10.1038/ejcn.2016.151
[Indexed for MEDLINE]

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