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BMC Complement Altern Med. 2016 Aug 30;16(1):327. doi: 10.1186/s12906-016-1322-7.

Hepatoprotective effect of Quercetin supplementation against Acrylamide-induced DNA damage in wistar rats.

Author information

1
Clinical Laboratory Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia. sansar@ksu.edu.sa.
2
Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
3
Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
4
Clinical Laboratory Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.

Abstract

BACKGROUND:

Quercetin (QR), is a polyphenolic flavonoid compound which is found in large amounts in certain foods, and protects against oxidative stress. The current study was conducted to determine whether Quercetin can possibly exert hepatoprotective and antioxidant activity against acrylamide (ACR) induced toxicity in rats.

METHODS:

Four groups of Wistar rats consisting of six rats each: (i) control group; (ii) ACR treated group (50 mg/kg bw); (iii) QR group: rats were treated with QR (10 mg/kg bw); (iv) QR (10 mg/kg bw) was given i.p. for 5 days followed by ACR (50 mg/kg bw) on 5th day (single dose).

RESULTS:

ACR caused an elevation in 8-OH guanosine level and a reduction in Glutahione S-transferase (GST) activity. Administration of QR significantly protected liver tissue against hepatotoxic effect of acrylamide from amelioration of the marker enzyme (p < 0.05) and DNA damage (p < 0.01) as evident by comet assay and, besides some indices of histopathological alterations.

CONCLUSION:

It is concluded that QR could protect the liver against DNA damage induced by ACR probably is thus capable of ameliorating ACR-induced changes in the rat livers.

KEYWORDS:

Antioxidants; DNA damage; Oxidative stress; Quercetin

PMID:
27576905
PMCID:
PMC5004263
DOI:
10.1186/s12906-016-1322-7
[Indexed for MEDLINE]
Free PMC Article

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