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Pediatr Radiol. 2016 Dec;46(13):1804-1812. Epub 2016 Aug 30.

Quantitative CT characterization of pediatric lung development using routine clinical imaging.

Author information

1
Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
2
Center for Pulmonary Imaging Research, Pulmonary Medicine & Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
3
Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA. Jason.Woods@cchmc.org.
4
Center for Pulmonary Imaging Research, Pulmonary Medicine & Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Jason.Woods@cchmc.org.

Abstract

BACKGROUND:

The use of quantitative CT analysis in children is limited by lack of normal values of lung parenchymal attenuation. These characteristics are important because normal lung development yields significant parenchymal attenuation changes as children age.

OBJECTIVE:

To perform quantitative characterization of normal pediatric lung parenchymal X-ray CT attenuation under routine clinical conditions in order to establish a baseline comparison to that seen in pathological lung conditions.

MATERIALS AND METHODS:

We conducted a retrospective query of normal CT chest examinations in children ages 0-7 years from 2004 to 2014 using standard clinical protocol. During these examinations semi-automated lung parenchymal segmentation was performed to measure lung volume and mean lung attenuation.

RESULTS:

We analyzed 42 CT examinations in 39 children, ages 3 days to 83 months (mean ± standard deviation [SD] = 42 ± 27 months). Lung volume ranged 0.10-1.72 liters (L). Mean lung attenuation was much higher in children younger than 12 months, with values as high as -380 Hounsfield units (HU) in neonates (lung volume 0.10 L). Lung volume decreased to approximately -650 HU by age 2 years (lung volume 0.47 L), with subsequently slower exponential decrease toward a relatively constant value of -860 HU as age and lung volume increased.

CONCLUSION:

Normal lung parenchymal X-ray CT attenuation decreases with increasing lung volume and age; lung attenuation decreases rapidly in the first 2 years of age and more slowly thereafter. This change in normal lung attenuation should be taken into account as quantitative CT methods are translated to pediatric pulmonary imaging.

KEYWORDS:

Children; Computed tomography; Lung attenuation; Lungs; Normal

PMID:
27576458
PMCID:
PMC5116406
DOI:
10.1007/s00247-016-3686-8
[Indexed for MEDLINE]
Free PMC Article

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