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Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):142-151. doi: 10.1016/j.ijheh.2016.08.001. Epub 2016 Aug 19.

The exposome in practice: Design of the EXPOsOMICS project.

Author information

1
MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, UK. Electronic address: p.vineis@imperial.ac.uk.
2
MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, UK.
3
Genedata AG, Basel, Switzerland.
4
International Agency for Research on Cancer (IARC), Lyon, France.
5
Maastricht University, Department of Health Risk Analysis and Toxicology, Maastricht, Netherlands.
6
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
7
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Division of Organic and Medicinal Chemistry, Athens, Greece.
8
King's College London, Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, London, UK.
9
Swiss Tropical School of Public Health, Department of Epidemiology and Public Health, Basel, Switzerland and University of Basel, Basel, Switzerland.
10
Utrecht University, Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht, Netherlands.

Abstract

EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple "omic" technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as 'exposome-wide association studies' (EWAS).

PMID:
27576363
PMCID:
PMC6192011
DOI:
10.1016/j.ijheh.2016.08.001
[Indexed for MEDLINE]
Free PMC Article

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