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Annu Rev Cell Dev Biol. 2016 Oct 6;32:649-675. Epub 2016 Aug 17.

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals.

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Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, D-48169 Münster, Germany; email:
Faculty of Medicine, University of Münster, D-48149 Münster, Germany.
Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel; email:


In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.


angiocrine factors; bone angiogenesis; hematopoietic stem cells; vascular niche

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