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Bioorg Med Chem Lett. 2016 Oct 1;26(19):4655-4660. doi: 10.1016/j.bmcl.2016.08.056. Epub 2016 Aug 21.

Anti-adipogenic and anti-diabetic effects of cis-3',4'-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro.

Author information

1
Department of Food and Nutrition, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 57922, Republic of Korea.
2
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea; Suncheon Research Center for Natural Medicines, Suncheon 57922, Republic of Korea.
3
Mokpo Marin Food-Industry Research Center, Mokpo 58621, Republic of Korea.
4
College of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea; Suncheon Research Center for Natural Medicines, Suncheon 57922, Republic of Korea.
5
College of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea.
6
Department of Biotechnology, Dong-A University, Busan 49315, Republic of Korea.
7
Functional Food & Nutrition Division, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, Republic of Korea.
8
Department of Bakery & Barista, Suseong College, Daegu 42078, Republic of Korea.
9
Department of Food and Nutrition, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 57922, Republic of Korea; Suncheon Research Center for Natural Medicines, Suncheon 57922, Republic of Korea. Electronic address: leemk@sunchon.ac.kr.

Abstract

Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3',4'-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (30 and 50μM) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBPα, PPARγ and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential α-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity.

KEYWORDS:

Adipocytes; Adipogenesis; Anti-diabetes; Anti-obesity; Peucedanum japonicum Thunb leaves

PMID:
27575482
DOI:
10.1016/j.bmcl.2016.08.056
[Indexed for MEDLINE]

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