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Nat Rev Immunol. 2016 Oct;16(10):612-25. doi: 10.1038/nri.2016.94. Epub 2016 Aug 30.

T follicular helper cells in space-time.

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Laboratory of Dynamic Immunobiology, Institute for Immunology, Department of Basic Biomedical Sciences, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Medical Science Building A107, Tsinghua University, Beijing 100084, China.


T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce long-lived, high-affinity plasma cells and memory B cells. TFH cells exhibit unique molecular, cellular and tissue-dynamic features that are integral to their development and function but that are not necessarily compatible with the classical paradigm of effector CD4(+) T cell differentiation. Here, I discuss recent advances in TFH cell biology and their implications for our understanding of T cell differentiation and memory in humoral immunity from spatiotemporal and functional perspectives.

[Indexed for MEDLINE]

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