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J Proteome Res. 2016 Nov 4;15(11):3979-3987. Epub 2016 Sep 20.

Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016.

Author information

1
Advanced Clinical BioSystems Research Institute, Department of Medicine, Cedars-Sinai Medical Centre , Los Angeles, California 90038, United States.
2
Department of Hepatology, Proteomics Laboratory, CIMA, University of Navarra; Ciberhed; PRB2, ProteoRed-ISCIII, 31008 Pamplona, Spain.
3
Department of Biology, Institute of Molecular Systems Biology, ETH Zürich , 8093 Zürich, Switzerland.
4
Institute for Systems Biology , Seattle, Washington 98109, United States.
5
Istituto Sperimentale Italiano L. Spallanzani , 20133 Milano, Italy.
6
Centre Medicale Universitaire , Human Protein Sciences Department, CH-1211 Geneva, Switzerland.
7
Niigata University , Department of Structural Pathology, Institute of Nephrology, Medical and Dental School, Asachimachi-dori Niigata 951-8510, Japan.
8
Fudan University , Department of Chemistry, Shanghai 200433, P.R. China.
9
Johns Hopkins University , Department of Pathology, Baltimore, Maryland 21287, United States.
10
Center for Computational Medicine and Bioinformatics, University of Michigan , Ann Arbor, Michigan 48109, United States.

Abstract

The Biology and Disease-driven Human Proteome Project (B/D-HPP) is aimed at supporting and enhancing the broad use of state-of-the-art proteomic methods to characterize and quantify proteins for in-depth understanding of the molecular mechanisms of biological processes and human disease. Based on a foundation of the pre-existing HUPO initiatives begun in 2002, the B/D-HPP is designed to provide standardized methods and resources for mass spectrometry and specific protein affinity reagents and facilitate accessibility of these resources to the broader life sciences research and clinical communities. Currently there are 22 B/D-HPP initiatives and 3 closely related HPP resource pillars. The B/D-HPP groups are working to define sets of protein targets that are highly relevant to each particular field to deliver relevant assays for the measurement of these selected targets and to disseminate and make publicly accessible the information and tools generated. Major developments are the 2016 publications of the Human SRM Atlas and of "popular protein sets" for six organ systems. Here we present the current activities and plans of the BD-HPP initiatives as highlighted in numerous B/D-HPP workshops at the 14th annual HUPO 2015 World Congress of Proteomics in Vancouver, Canada.

KEYWORDS:

B/D-HPP; Biology and Disease-driven Human Proteome Project; MS; SRM−MS; mass spectrometry; selected reaction monitoring−MS

PMID:
27573249
PMCID:
PMC5129618
DOI:
10.1021/acs.jproteome.6b00444
[Indexed for MEDLINE]
Free PMC Article

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