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Int J Environ Res Public Health. 2016 Aug 26;13(9). pii: E850. doi: 10.3390/ijerph13090850.

25 Hydroxyvitamin D Deficiency and Its Relationship to Autoimmune Thyroid Disease in the Elderly.

Author information

1
I.O.S. & COLEMAN Srl, Via Alcide De Gasperi, 107,109,111, Acerra (NA) 80011, Italy. giovanna.muscogiuri@gmail.com.
2
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy. daniela.mari@unimi.it.
3
Geriatric Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy. daniela.mari@unimi.it.
4
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy. prolo@libero.it.
5
Geriatric Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy. prolo@libero.it.
6
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Piazzale Brescia 20, Milan 20149, Italy. l.fatti@auxologico.it.
7
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy. celeste.cantone@gmail.com.
8
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via San Giacomo 12, Bologna 40126, Italy. paolo.garagnani2@unibo.it.
9
Interdepartmental Center "L. Galvani" (C.I.G.), University of Bologna, Via San Giacomo 12, Bologna 40126, Italy. paolo.garagnani2@unibo.it.
10
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy. beatrice.arosio@unimi.it.
11
Geriatric Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy. beatrice.arosio@unimi.it.
12
IRCCS SDN, Napoli Via Gianturco 113, Naples 80143, Italy. cdisomma@unina.it.
13
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy. giovanni.vitale@unimi.it.
14
Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Via Zucchi 18, Cusano Milanino (MI) 20095, Italy. giovanni.vitale@unimi.it.

Abstract

BACKGROUND:

Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroiditis (AT). The aim of the study was to investigate the association of AT with low 25(OH) vitamin D levels in the elderly.

METHODS:

One hundred sixty-eight elderly subjects (mean age: 81.6 ± 9.4 years) were enrolled. Serum levels of 25(OH) vitamin D, anti-thyroid peroxidase (TPO-Ab), anti-thyroglobulin (TG-Ab) antibodies, free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were measured.

RESULTS:

The prevalence of AT was significantly higher in subjects with vitamin D deficiency (25(OH) vitamin D < 20 ng/mL) when compared with subjects with normal 25(OH) vitamin D (25(OH) vitamin D ≥ 20 ng/mL) levels (28% vs. 8%, respectively, p = 0.002). Patients with AT and vitamin D deficiency had a comparable hormonal profile compared to patients with AT and vitamin D sufficiency in terms of TSH (p = 0.39), FT3 (p = 0.30), FT4 (p = 0.31), TG-Ab (0.44) and TPO-Ab (0.35). Interestingly, a significant correlation between 25(OH) vitamin D and TPO-Ab (r = -0.27, p = 0.03) and FT3 (r = 0.35, p = 0.006) has been found in subjects with AT while no correlation was found between 25(OH) vitamin D levels and TG-Ab (r = -0.15, p = 0.25), TSH (r = -0.014, p = 0.09) and FT4 (r = 0.13, p = 0.32).

CONCLUSIONS:

These findings suggest that vitamin D deficiency was significantly associated with AT in the elderly. Therefore, the screening for AT should be suggested in subjects with vitamin D deficiency.

KEYWORDS:

autoimmune thyroid disease; elderly; environment; lifestyle; vitamin D

PMID:
27571093
PMCID:
PMC5036683
DOI:
10.3390/ijerph13090850
[Indexed for MEDLINE]
Free PMC Article

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