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Obesity (Silver Spring). 2016 Oct;24(10):2232-9. doi: 10.1002/oby.21612. Epub 2016 Aug 29.

Body mass index and all-cause mortality among older adults.

Author information

1
Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
2
Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA. xxg14@psu.edu.
3
Department of Internal Medicine & the Obesity Institute, Geisinger Health System, Danville, Pennsylvania, USA.
4
Dean's Office and Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.

Abstract

OBJECTIVE:

To examine the association between baseline body mass index (BMI, kg/m(2) ) and all-cause mortality in a well-characterized cohort of older persons.

METHODS:

The association between BMI (both as a categorical and continuous variable) and all-cause mortality was investigated using 4,565 Geisinger Rural Aging Study participants with baseline age 74.0 ± 4.7 years (mean ± SD) and BMI 29.5 ± 5.3 kg/m(2) over a mean of 10.9 ± 3.8 years of follow-up.

RESULTS:

The relationship between BMI (as a continuous variable) and all-cause mortality was found to be U-shaped (P nonlinearity <0.001). Controlling for age, sex, smoking, alcohol, laboratory values, medications, and comorbidity status, underweight (BMI <18.5 kg/m(2) ) individuals had significantly greater adjusted risk of all-cause mortality than persons of BMI 18.5 to 24.9 kg/m(2) (reference range). Participants with overweight (BMI 25.0-29.9 kg/m(2) ) and class I obesity (BMI 30.0-34.9 kg/m(2) ) had significantly lower adjusted-risk of all-cause mortality. Those with classes II/III obesity (BMI ≥ 35.0 kg/m(2) ) did not have significantly greater adjusted-risk of all-cause mortality. Findings were consistent using propensity score weights and among never-smokers with 2- and 5-year lag analysis and among those with no identified chronic disease.

CONCLUSIONS:

A U-shaped association was observed between BMI and all-cause mortality with lower risk among older persons with overweight and class I obesity in comparison with those with BMI 18.5 to 24.9 kg/m(2) .

PMID:
27570944
DOI:
10.1002/oby.21612
[Indexed for MEDLINE]
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