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Orv Hetil. 2016 Aug;157(35):1403-9. doi: 10.1556/650.2016.30516.

[Monitoring cytomegalovirus infection and reactivation using quantitative real-time polymerase chain reaction in patients with haematological malignancies during chemotherapy and after autologous stem cell transplantation].

[Article in Hungarian]

Author information

1
II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6721.
2
Klinikai Mikrobiológiai Diagnosztikai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.
3
Pathologiai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.

Abstract

INTRODUCTION:

Because of the use of chemo-immunotherapeutic drugs, cytomegalovirus infection is one of the most important infectious complications among patients with haematological malignancies.

AIM:

The aim of the authors was to detect cytomegalovirus infection and reactivation using quantitative real-time polymerase chain reaction.

METHOD:

Between 2012 and 2014, the authors retrospectively analysed 96 patient's medical history hospitalised in haematology Unit. Patients were grouped on the basis of their underlying diseases (lymphoprolipherative malignancies, acute leukaemias), and the following groups were created: autologous stem cell transplanted and non-transplanted groups.

RESULTS:

Eighty-three patients were treated with lymphoprolipherative disorders, and 63 (76%) of them underwent autologous stem cell transplantation. Out of the 604 plasma specimens 46 (7.6%) were positive for the cytomegalovirus desoxyribonucleic acid collected from 25 patients [6 non-transplanted (18%) and 19 from the transplanted group (30.2%)]. The frequency of cytomegalovirus positivity was doubled in the transplanted patient group, however, reactivation was asymptomatic in 68% of the cases.

CONCLUSIONS:

The routine use of cytomegalovirus monitoring is not necessary in this patient group. In case of suspected cytomegalovirus infection, molecular tests allow early preemptive antiviral therapy, which may decrease the mortality attributed to cytomegalovirus infection. Orv. Hetil., 2016, 157(35), 1403-1409.

KEYWORDS:

cytomegalovirus; cytomegalovirus (CMV); immunocompromised; immunszupprimált; molecular; molekuláris

PMID:
27569463
DOI:
10.1556/650.2016.30516
[Indexed for MEDLINE]

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