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Urology. 2016 Nov;97:160-165. doi: 10.1016/j.urology.2016.08.027. Epub 2016 Aug 26.

High-resolution Map of Somatic Periprostatic Nerves.

Author information

1
Departments of Urology and Surgery, University of Melbourne, The Royal Melbourne Hospital, Australia. Electronic address: fairleighr@gmail.com.
2
TissuPath Pty Ltd, Mount Waverley, Australia.
3
Department of Urology, New York University, New York, NY.
4
Departments of Urology and Surgery, University of Melbourne, The Royal Melbourne Hospital, Australia; Australian Prostate Cancer Centre, Epworth Hospital, Australia.

Abstract

OBJECTIVE:

To generate a high-resolution map of periprostatic somatic nerves. Periprostatic nerves are at risk of injury during radical prostatectomy; this study aimed to establish the location of somatic nerves with respect to the prostate and the neurovascular bundle.

MATERIALS AND METHODS:

Hemiprostates from patients in whom a wide local excision was performed were evaluated. Representative sections from the base, midzone, and apex of the prostate were stained with Masson's trichrome and antineuronal nitric oxide synthase antibodies, to identify myelinated and parasympathetic nerves, respectively. Somatic nerves were identified as neuronal nitric oxide synthase negative myelinated nerves. Stained slides were scanned (40× objective) for digital analysis. Location of nerves was described with reference to 6 equal sectors per hemiprostate.

RESULTS:

Somatic nerves account for almost 5% of all nerve fibers in the periprostatic tissue. This study found a mean somatic nerve count of 5.83, 5.25, and 3.67 at the level of the prostate base, midzone, and apex, respectively. These nerves are most frequently located either anteriorly or in the region of the neurovascular bundle (posterolateral).

CONCLUSION:

Somatic nerves in the periprostatic region are at risk of injury during radical prostatectomy. Further research is required to clarify their functional relevance.

PMID:
27569453
DOI:
10.1016/j.urology.2016.08.027
[Indexed for MEDLINE]

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