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Trends Cell Biol. 2016 Dec;26(12):956-967. doi: 10.1016/j.tcb.2016.07.009. Epub 2016 Aug 24.

β-Catenin-Independent Roles of Wnt/LRP6 Signaling.

Author information

1
Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany. Electronic address: s.perezacebron@DKFZ-Heidelberg.de.
2
Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology, 55128 Mainz, Germany. Electronic address: Niehrs@DKFZ-Heidelberg.de.

Abstract

Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.

KEYWORDS:

GSK3; Wnt/STOP; mitosis; post-transcriptional Wnt signaling; proteolysis; β-catenin

PMID:
27568239
DOI:
10.1016/j.tcb.2016.07.009
[Indexed for MEDLINE]

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