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Int Urol Nephrol. 2016 Dec;48(12):1961-1966. Epub 2016 Aug 27.

Advantage of urine based molecular diagnosis of Zika virus.

Author information

1
Department of Urology, William Beaumont Hospital, 3811 West 13 Mile Road, Suite 187, Royal Oak, MI, 48073, USA. laura.lamb@beaumont.org.
2
Department of Urology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA. laura.lamb@beaumont.org.
3
Department of Urology, William Beaumont Hospital, 3811 West 13 Mile Road, Suite 187, Royal Oak, MI, 48073, USA.
4
Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.
5
Department of Urology, Fundación Santa Fe de Bogotá University Hospital, Bogotá D.C., Colombia.
6
School of Medicine, Universidad de Los Andes, Bogotá D.C., Colombia.
7
Subdireccion de Estudios Clínicos, Fundación Santa Fe de Bogotá University Hospital, Bogotá D.C., Colombia.
8
Department of Urology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.

Abstract

Zika virus (ZIKV) infection is an emerging global health concern, and diagnostic recommendations are currently developing based on new information. Several case or small sample size studies using both urine and blood samples suggest that ZIKV RNA can be detected at higher levels and for a longer time after onset of infection in urine compared to blood. We recommend that urine and serum collection for molecular testing be a standard part of evaluating patients for ZIKV infection, and that urine is a good alternative testing sample when blood collection is problematic.

KEYWORDS:

Molecular diagnostic; Urine biomarker; Zika infection; Zika virus

PMID:
27567913
DOI:
10.1007/s11255-016-1406-9
[Indexed for MEDLINE]

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