Send to

Choose Destination
J Alzheimers Dis. 2016 Oct 4;54(3):1039-1045.

Primary Progressive Orofacial Apraxia: A Ten-Year Long Follow-Up Case Report.

Author information

Department of Neurology and Psychiatry, Sapienza, University of Rome, Italy.
School of Psychology, University of South Wales, Pontypridd, UK.


Orofacial apraxia (OA) as the main symptom in neurodegenerative disorders has not been yet reported. We present the case of a woman with a 22-month long history of isolated OA, studied with cerebrospinal fluid biomarkers and repeated clinical, neuropsychological, and morpho-functional evaluations. Baseline morpho-functional neuroimages revealed a left frontal operculum hypoperfusion with a widespread fronto-temporal involvement at follow-up. Cerebrospinal fluid concentrations of tau and amyloid-β were normal. The ten-year long clinical observation disclosed progressive OA worsening and the late onset of frontal functions impairment and extrapyramidal signs. The early and late stages of a neurodegenerative syndrome with OA as the main clinical feature were characterized.


Apraxia of speech; cerebrospinal fluid biomarkers; frontotemporal lobar degeneration; orofacial apraxia; primary progressive aphasia; primary progressive apraxia of speech; single-photon emission computed tomography

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for IOS Press
Loading ...
Support Center