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J Alzheimers Dis. 2016 Oct 18;54(4):1291-1295.

Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis.

Author information

1
Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes Cedex 4, France.
2
Laboratoire de Biochimie-Protéomique Clinique - IRMB - CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex 5, France.
3
Centre Mémoire de Ressources et de Recherche Montpellier, Département de Neurologie, CHU Montpellier, Hôpital Gui de Chauliac - Université de Montpellier, Montpellier Cedex 5, France.
4
Department of biostatistics (BESPIM), Nîmes University Hospital, Nîmes cedex 9, France.
5
Institut de Génomique Fonctionnelle, UMR5203, Université Montpellier, Montpellier Cedex 5, France.

Abstract

We evaluated cerebrospinal fluid amyloid-β 1-40 (Aβ40), amyloid-β 1-42 (Aβ42), total and phosphorylated-tau (t-tau and p-tau) in patients with symptomatic isolated cortical supratentorial superficial siderosis (SS), by prospectively recruiting ten patients with SS in the absence of pre-existing cognitive dysfunction, and comparing biomarkers with lobar hematoma cerebral amyloid angiopathy patients (LH-CAA, n = 13), Alzheimer's disease patients (AD, n = 42), and controls (n = 16). Compared to controls, SS patients showed statistically significant higher t-tau (p = 0.019) and lower Aβ42 (p = 0.0084). Compared to other groups, SS showed statistically significant lower t-tau, p-tau, and Aβ40 compared to AD (p = 0.0063, p = 0.0004, and p = 0022, respectively), and higher p-tau compared to LH-CAA (p = 0.012).

KEYWORDS:

Amyloid-β; cerebral amyloid angiopathy; cerebrospinal fluid; superficial siderosis; tau

PMID:
27567848
DOI:
10.3233/JAD-160400
[Indexed for MEDLINE]

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