Format

Send to

Choose Destination
Semin Cell Dev Biol. 2016 Dec;60:38-45. doi: 10.1016/j.semcdb.2016.08.020. Epub 2016 Aug 24.

Biology of rhomboid proteases in infectious diseases.

Author information

1
Department of Microbiology and Molecular Medicine, University of Geneva, CMU, 1 Rue Michel-Servet, CH-1211 Geneva 4, Switzerland. Electronic address: Sunil.Dogga@unige.ch.
2
Department of Microbiology and Molecular Medicine, University of Geneva, CMU, 1 Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.

Abstract

Rhomboids are a well-conserved class of intramembrane serine proteases found in all kingdoms of life, sharing a conserved core structure of at least six transmembrane (TM) domains that contain the catalytic serine-histidine dyad. The rhomboid proteases, which cleave membrane embedded substrates within their TM domains, are emerging as an important group of enzymes controlling a myriad of biological processes. These enzymes are found in a wide variety of pathogens manifesting important roles in their pathological processes. Accordingly, they have received considerable attention as potential targets for pharmacological intervention over the past few years. This review provides a general update on rhomboid proteases and their roles in pathogenesis of human infectious agents.

KEYWORDS:

Adhesins; Apicomplexa; Intramembrane proteolysis; Mycobacteria; Parasites; Protozoan pathogens; Rhomboid proteases

PMID:
27567708
DOI:
10.1016/j.semcdb.2016.08.020
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center