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Clin Gastroenterol Hepatol. 2017 Apr;15(4):584-593.e2. doi: 10.1016/j.cgh.2016.07.035. Epub 2016 Aug 25.

Acute Rejection Increases Risk of Graft Failure and Death in Recent Liver Transplant Recipients.

Author information

1
Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: j-levitsky@northwestern.edu.
2
Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
3
Arbor Research Collaborative for Health, Ann Arbor, Michigan; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.
4
Arbor Research Collaborative for Health, Ann Arbor, Michigan.
5
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.
6
Arbor Research Collaborative for Health, Ann Arbor, Michigan; Section of Transplantation, University of Michigan, Ann Arbor, Michigan.
7
Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.
8
University of Toronto, Toronto, Ontario, Canada.
9
Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
10
Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
11
Division of Transplant Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Abstract

BACKGROUND & AIMS:

Acute rejection is detrimental to most transplanted solid organs, but is considered to be less of a consequence for transplanted livers. We evaluated risk factors for and outcomes after biopsy-proven acute rejection (BPAR) based on an analysis of a more recent national sample of recipients of liver transplants from living and deceased donors.

METHODS:

We analyzed data from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) from 2003 through 2014 as the exploratory cohort and the Scientific Registry of Transplant Recipients (SRTR) from 2005 through 2013 as the validation cohort. We examined factors associated with time to first BPAR using multivariable Cox regression or discrete-survival analysis. Competing risks methods were used to compare causes of death and graft failure between recipients of living and deceased donors.

RESULTS:

At least 1 BPAR episode occurred in 239 of 890 recipients in A2ALL (26.9%) and 7066 of 45,423 recipients in SRTR (15.6%). In each database, risk of rejection was significantly lower when livers came from biologically related living donors (A2ALL hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.43-0.76; and SRTR HR, 0.78; 95% CI, 0.66-0.91) and higher in liver transplant recipients with primary biliary cirrhosis, of younger age, or with hepatitis C. In each database, BPAR was associated with significantly higher risks of graft failure and death. The risks were highest in the 12 month post-BPAR period in patients whose first episode occurred more than 1 year after liver transplantation: HRs for graft failure were 6.79 in A2ALL (95% CI, 2.64-17.45) and 4.41 in SRTR (95% CI, 3.71-5.23); HRs for death were 8.81 in A2ALL (95% CI, 3.37-23.04) and 3.94 in SRTR (95% CI, 3.22-4.83). In analyses of cause-specific mortality, associations were observed for liver-related (graft failure) causes of death but not for other causes.

CONCLUSIONS:

Contrary to previous data, acute rejection after liver transplant is associated with significantly increased risk of graft failure, all-cause mortality, and graft failure-related death, regardless of primary liver disease etiology. Living donor liver transplantation from a biologically related donor is associated with decreased risk of rejection.

KEYWORDS:

Database Analysis; LT; Risk Factor; Survival

PMID:
27567694
PMCID:
PMC5326609
DOI:
10.1016/j.cgh.2016.07.035
[Indexed for MEDLINE]
Free PMC Article

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