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Transfus Apher Sci. 2016 Dec;55(3):302-307. doi: 10.1016/j.transci.2016.08.001. Epub 2016 Aug 5.

Profile of Rh, Kell, Duffy, Kidd, and Diego blood group systems among blood donors in the Southwest region of the Paraná state, Southern Brazil.

Author information

1
Department of Analyses Clinical and Biomedicine, Post Graduation Program of Biosciences and Physiopathology, Maringa State University, Maringá, Paraná, Brazil. Electronic address: jo_maira@hotmail.com.
2
Department of Analyses Clinical and Biomedicine, Post Graduation Program of Biosciences and Physiopathology, Maringa State University, Maringá, Paraná, Brazil.
3
Basic Health Sciences Department, Maringa State University, Maringá, Paraná, Brazil.

Abstract

The aim of this study was to assess the distribution of alleles and genotypes of the blood group systems Rh, Kell, Duffy, Kidd, and Diego in 251 regular blood donors registered in the hemotherapy unit of the Southwestern region of Paraná, Southern Brazil. The frequencies were obtained by direct counting on a spreadsheet program and statistical analyses were conducted in order to compare them with other Brazilian populations using chi-squared with Yates correction on OpenEpi software. The frequencies of RHD* negative, RHCE*c/c and RHCE*e/e were higher than expected for the Caucasian population. A difference was also observed for FY alleles, FY*01/FY*01 genotype and FY*02N.01 -67T/C (GATA Box mutation). Two homozygous individuals were defined as a low frequency phenotype K + k- (KEL*01.01/KEL*01.01) and, for Diego blood group system the rare DI*01 allele was found in ten blood donors, of which one was DI*01/DI* 01 (0.4%). The allele and genotype frequencies of Kidd blood group system were similar to expected to Caucasians. The results showed the direction in which to choose donors, the importance of extended genotyping in adequate blood screening and the existence of rare genotypes in Brazilian regular blood donors.

KEYWORDS:

Blood transfusion; Genetic; Genotyping; Polymorphism

PMID:
27566949
DOI:
10.1016/j.transci.2016.08.001
[Indexed for MEDLINE]

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