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Biomed Pharmacother. 2016 Oct;83:1233-1238. doi: 10.1016/j.biopha.2016.08.038. Epub 2016 Aug 23.

Therapeutic effect of apple pectin in obese rats.

Author information

1
Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia; Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia. Electronic address: samout_noura@hotmail.fr.
2
Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia; Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
3
Unity of Commun Services, Faculty of sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
4
Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia.

Abstract

Obesity is the most common nutritional disorder and is associated with significant comorbidities such as dyslipidemia, atherosclerosis and type 2 diabetes. This pathology is changing worldwide and is a risk factor for cardiovascular disease. This study, carried out on adult male Wistar rats, evaluates the inhibitory effects of supplementation with apple pectin molecule on obesity. Under our experimental conditions, administration of pectin molecule decreased 1) the total cholesterol (TC), LDL-cholesterol (LDL-ch) and triglycerides (TG) levels as well as ASAT, ALAT, LDH, ALP, UREA and uric acid (UC) levels in blood serum; and 2) increased the creatinine levels (CREA), compared to HFD group. TBARS concentrations decreased in liver, kidney, and serum by 20%, 29% and 19%, respectively, in a group treated with high-fat diet and pectin (HFD+Pec) compared to a HFD-treated group. The same treatment with pectin molecule increased superoxide dismutase, glutathion peroxidase and catalase activities by 39%, 14% and 16% in liver; 5%, 7% and 31% in kidney; and 9%, 32% and 22% in blood serum in the HFD Pec-treated group. The anti-obesity effects of the pectin molecule in several organs are mainly due to the interaction of this molecule with both the polysaccharide and the enzyme system which can be determined by phytochemical analysis.

KEYWORDS:

Antioxidant enzymes; DPPH; FTIR; Lipid peroxidation (TBARS); Obese rats; Pectin molecule

PMID:
27565845
DOI:
10.1016/j.biopha.2016.08.038
[Indexed for MEDLINE]

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