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J Urol. 2017 Feb;197(2):423-431. doi: 10.1016/j.juro.2016.08.087. Epub 2016 Aug 24.

Nocturnal Polyuria and Hypertension in Patients with Lifestyle Related Diseases and Overactive Bladder.

Author information

1
Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, Japan. Electronic address: oyoko@u-fukui.ac.jp.
2
North Alps Medical Center Azumi Hospital, Kitaazumi, Japan.
3
Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
4
Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan.
5
Department of Urology, Nagoya University Graduate School of Medicine, Aichi, Japan.
6
Department of Renal and Urologic Surgery, Asahikawa Medical University, Asahikawa, Japan.
7
Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, Japan.
8
Tokyo Dental College, Ichikawa General Hospital, Ichikawa, Japan.
9
Biostatistics Center, Kurume University, Kurume, Japan.

Abstract

PURPOSE:

The objective of this multicenter cross-sectional study was to investigate the relationship of nocturnal polyuria in patients with common lifestyle related diseases and overactive bladder, with special attention to hypertension.

MATERIALS AND METHODS:

After baseline assessment, patients recorded 24-hour urinary frequency/volume, blood pressure and heart rate for 3 days. They were stratified into 4 groups based on mean blood pressure, including no hypertension, and controllable, untreated and uncontrolled hypertension, respectively.

RESULTS:

The 2,353 eligible patients, who had urinary urgency once or more per week and 1 or more nocturnal toilet visits, were enrolled from 543 sites in Japan. Of these patients complete data, including the 24-hour frequency volume chart, were collected from 1,271. Multivariable analyses showed a statistically significant association of nocturnal polyuria with increasing age (OR 1.04, 95% CI 1.02-1.05, p <0.001) and gender (women vs men OR 0.75, 95% CI 0.59-0.96, p = 0.02), and for controllable (OR 1.10, 95% CI 0.83-1.460), untreated (OR 2.62, 95% CI 1.55-4.45) and uncontrolled (OR 1.15, 95% CI 0.81-1.62) hypertension vs no hypertension (p = 0.005). However, when assessed separately in men and women, hypertension and heart rate were significantly associated with nocturnal polyuria in women alone (p = 0.01 and 0.03, respectively). Lower urinary tract symptoms suggestive of benign prostatic hyperplasia were significantly associated with nocturnal polyuria in men alone (p <0.001).

CONCLUSIONS:

The current study demonstrates that nocturnal polyuria was significantly associated with age, male gender, and untreated hypertension in patients with lifestyle related diseases and overactive bladder. The association between hypertension and nocturnal polyuria was significant in women alone.

KEYWORDS:

hypertension; life style; nocturia; overactive; polyuria; urinary bladder

PMID:
27565397
DOI:
10.1016/j.juro.2016.08.087
[Indexed for MEDLINE]

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