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Fertil Steril. 2016 Nov;106(6):1399-1406. doi: 10.1016/j.fertnstert.2016.07.1098. Epub 2016 Aug 24.

Prevalences and pregnancy outcome of vanishing twin pregnancies achieved by in vitro fertilization versus natural conception.

Author information

1
Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary. Electronic address: martonvirag@gmail.com.
2
Center for Assisted Reproduction, Kaáli Institute, University of Szeged, Szeged, Hungary.
3
Department of Obstetrics and Gynecology, Blekinge Hospital, Karlskrona, Sweden.
4
Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary.

Abstract

OBJECTIVE:

To evaluate whether vanishing twin (VT) pregnancies achieved by in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) had a more adverse perinatal outcome than those after natural conception.

DESIGN:

Longitudinal, retrospective cohort study.

SETTING:

Tertiary university hospital.

PATIENT(S):

Three hundred and six (78 after IVF-ICSI and 228 after natural conception) VT pregnancies over a 22-year period, with VT cases matched to primarily singleton controls.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Obstetric and neonatal outcome data.

RESULT(S):

The incidence of VT was statistically significantly higher after natural conception (18.2% of twins) than after IVF-ICSI (12.6% of twins). The odds of VT in pregnancies complicated with pregestational or gestational diabetes were disproportionally higher in IVF-ICSI cases than in spontaneously conceived VT pregnancies (adjusted odds ratio [AOR]: 0.80 vs. 3.10 and 1.00 vs. 1.07, respectively). Previous induced abortion (AOR 1.34) or second-trimester fetal loss (AOR 3.3) increased the risk of VT pregnancies after spontaneous conception. Gestational diabetes mellitus in both the previous (AOR 5.41) and the present (AOR 2.3) pregnancy as well as chronic maternal diseases (AOR 3.5) and placentation anomalies all represented independent risk factors for VT after IVF-ICSI.

CONCLUSION(S):

Vanishing twin pregnancies had a lower prevalence and a worse perinatal outcome after IVF-ICSI as compared with those of their spontaneously conceived counterparts.

KEYWORDS:

IVF–ICSI; natural conception; perinatal outcome; singleton pregnancy; vanishing twin

[Indexed for MEDLINE]

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