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Can J Physiol Pharmacol. 2016 Oct;94(10):1102-1105. Epub 2016 Aug 7.

Hypotensive, cardiodepressant, and vasorelaxant activities of black currant (Ribes nigrum 'Ben Sarek') juice.

Author information

1
a Department of Physiology, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
2
b Department of Pharmacy, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
3
c Institute for Medicinal Plants Research "Josif Pančić", Tadeuša Košćuška 1, Belgrade, Serbia.

Abstract

The aim of this study was to evaluate the effects of black currant (Ribes nigrum L. 'Ben Sarek') juice on the blood pressure and frequency of cardiac contractions, as well as vasomotor responses of rat aortic rings. Arterial blood pressure was measured directly from the carotid artery in the anaesthetized rabbits. The aortic rings were pre-contracted with KCl (80 mmol·L-1), after which black currant juice was added. An intravenous injection of black currant juice (0.33-166.5 mg·kg-1) induced a significant and dose-dependent decrease of rabbit arterial blood pressure and heart rate. The black currant juice decreased arterial blood pressure of rabbit by 22.33% ± 3.76% (p < 0.05) and heart rate by 17.18% ± 2.93% (p < 0.05). Cumulative addition of the black currant juice (0.01-3 mg·mL-1) inhibited concentration-dependent KCl induced contractions of the isolated rat aorta. The black currant juice, at the concentration of 3 mg·mL-1, caused a maximum relaxation of 21.75% ± 3.15% (p < 0.05). These results demonstrate that black currant juice can induce hypotension. The hypotensive effect of the black currant may occur as the consequence of its inhibitory activity on the rate of heart contraction and vasorelaxant effects.

KEYWORDS:

activité de dépression de la fonction cardiaque; activité hypotensive; black currant; cardiodepressant activity; cassis; hypotensive activity; juices; jus; vasorelaxation

PMID:
27564244
DOI:
10.1139/cjpp-2015-0584

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