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Adv Mater. 2016 Oct;28(40):8927-8936. doi: 10.1002/adma.201602193. Epub 2016 Aug 25.

Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu2-x Se Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer.

Author information

1
Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
2
Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, Wollongong, NSW, 2522, Australia.
3
Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China. zhenli@suda.edu.cn.
4
Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, Wollongong, NSW, 2522, Australia. zhenli@suda.edu.cn.

Abstract

Ultrasmall PEGylated Cu2-x Se nanoparticles with strong near-infrared absorption have been prepared by an ambient aqueous method. The resultant water-soluble and biocompatible nanoparticles are demonstrated to be a novel nanotheranostic agent for effective deep-tissue photoacoustic imaging, computed tomography imaging, single-photon emission computed tomography imaging, and photothermal therapy of cancer.

KEYWORDS:

Cu2-xSe nanoparticles; computed tomography imaging; photoacoustic imaging; photothermal therapy; single-photon emission computed tomography

PMID:
27560922
DOI:
10.1002/adma.201602193

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