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Appl Physiol Nutr Metab. 2016 Sep;41(9):1005-7. doi: 10.1139/apnm-2016-0178. Epub 2016 Jun 13.

Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men.

Author information

1
a Applied Bioenergetics Lab, Biomedical Sciences Department, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, Novi Sad 21000, Serbia.
2
b University of Belgrade School of Medicine, Belgrade, Serbia.
3
c University Clinical Center of Vojvodina, Novi Sad, Serbia.
4
d Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.

Abstract

In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues.

KEYWORDS:

Vastus medialis muscle; bioenergetics; bioénergétique; cerebellum; cervelet; homocysteine; homocystéine; muscle vaste interne

PMID:
27560540
DOI:
10.1139/apnm-2016-0178
[Indexed for MEDLINE]

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