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PLoS One. 2016 Aug 25;11(8):e0161162. doi: 10.1371/journal.pone.0161162. eCollection 2016.

Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial.

Author information

1
Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.
2
Department of Anatomy, School of Medicine, Chungnam National University, Daejeon, Korea.

Abstract

BACKGROUND:

Vitamin D plays an important role in the immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis and psoriasis. Acne is a common inflammatory skin disease; however, the association with vitamin D remains unclear.

OBJECTIVES:

We evaluated vitamin D levels in patients with acne to determine the effect of vitamin D supplementation.

METHODS:

This study included 80 patients with acne and 80 healthy controls. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured, and demographic data were collected. Vitamin D-deficient patients were treated with oral cholecalciferol at 1000 IU/day for 2 months.

RESULTS:

Deficiency in 25(OH)D was detected in 48.8% of patients with acne, but in only 22.5% of the healthy controls. The level of 25(OH)D was inversely associated with the severity of acne, and there was a significant negative correlation with inflammatory lesions. In a subsequent trial, improvement in inflammatory lesions was noted after supplementation with vitamin D in 39 acne patients with 25(OH)D deficiency.

LIMITATIONS:

Limitations of the study include the small number of patients in the supplementation study and the natural fluctuation of acne.

CONCLUSIONS:

Vitamin D deficiency was more frequent in patients with acne, and serum 25(OH)D levels were inversely correlated with acne severity, especially in patients with inflammatory lesions.

PMID:
27560161
PMCID:
PMC4999291
DOI:
10.1371/journal.pone.0161162
[Indexed for MEDLINE]
Free PMC Article

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