Send to

Choose Destination
J Nutr Gerontol Geriatr. 2016 Jul-Sep;35(3):209-18. doi: 10.1080/21551197.2016.1206762.

Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.

Author information

a Department of Nutrition, Faculty of Health , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
b Yazd Diabetic Research Center , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
c Department of Internal Medicine , Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
d Department of Pharmacology and Applied Medicine , Institute of Medical Plants, ACECR , Karaj , Iran.


There is limited evidence that ginger powder consumption can relieve pain and inflammation due to specific anti-inflammatory phytochemical constitutents. This study investigates the effect of ginger supplementation on proinflammatory factors in participants (n = 120) of a randomized double-blind placebo-controlled 3-month clinical trial investigating knee osteoarthritis. Patients were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG). Administered daily for 3 months, participants in the GG intervention received capsules containing 500 mg of ginger powder, while PG participants received capsules filled with 500 mg starch. Serum samples collected at baseline and 3 months were analyzed for serum levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). At baseline, proinflammatory cytokine concentrations did not differ by group. However, at 3 months, both cytokines decreased in the GG relative to the PG. The results of this study indicate that ginger supplementation may have a promising benefits for knee osteoarthritis and may, therefore, may warrant further study.


Osteoarthritis; ginger; inflammation

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center