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Can J Gastroenterol Hepatol. 2016;2016:6940374. doi: 10.1155/2016/6940374. Epub 2016 Jul 31.

Functional Capacity, Respiratory Muscle Strength, and Oxygen Consumption Predict Mortality in Patients with Cirrhosis.

Author information

1
Graduate Program in Hepatology, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
2
Graduate Program in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
3
Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.

Abstract

INTRODUCTION:

Liver diseases influence musculoskeletal functions and may negatively affect the exercise capacity of patients with cirrhosis.

AIM:

To test the relationship between the six-minute walk test (6MWT), maximal inspiratory pressure (MIP), and exercise capacity (VO2peak) measures and the survival rate of patients with cirrhosis.

METHODS:

This prospective cohort study consisted of 86 patients diagnosed with cirrhosis with the following aetiology: hepatitis C virus (HCV), hepatitis B virus (HBV), and/or alcoholic cirrhosis (AC). All patients were followed up for three years and submitted to the 6MWT, pressure measurements with a compound gauge, and an exercise test (VO2peak).

RESULTS:

The survival analysis showed that the individuals who covered a distance shorter than 410 m during the 6MWT had a survival rate of 55% compared with a rate of 97% for the individuals who walked more than 410 m (p = 0.0001). Individuals with MIPs below -70 cmH2O had a survival rate of 62% compared with a rate of 93% for those with MIPs above -70 cmH2O (p = 0.0001). The patients with values below 17 mL/kg had a survival rate of 55% compared with a rate of 94% for those with values above 17 mL/kg (p = 0.0001).

CONCLUSION:

The 6MWT distance, MIP, and oxygen consumption are predictors of mortality in patients with cirrhosis.

PMID:
27559536
PMCID:
PMC4983318
DOI:
10.1155/2016/6940374
[Indexed for MEDLINE]
Free PMC Article

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