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Cancer Invest. 2016 Sep 13;34(8):393-400. doi: 10.1080/07357907.2016.1217422. Epub 2016 Aug 24.

Combined Expression of c-jun, c-fos, and p53 Improves Estimation of Prognosis in Oral Squamous Cell Carcinoma.

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a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
b Department of Oral Medicine , Heilongjiang Nursing College , Harbin , China.


To identify the prognostic value of c-jun, c-fos, and p53 in oral cancer, we examined the impact of immunohistochemical expression of these markers on tumor progression in 157 oral squamous cell carcinoma (OSCC). We found that c-jun or c-fos was significantly associated with lymph node metastasis, and coexpression of c-jun/c-fos, or c-jun/c-fos/p53 were significantly associated with lymph node metastasis, poor differentiation and clinical stage. The coexpression of c-jun/c-fos/p53 was identified as independent prognostic factors for overall survival. Simultaneous coexpression of these markers in OSCCs might prove to be a useful indicator for differentiation of low and high-risk patients.


Oral squamous cell carcinoma; c-fos; c-jun; p53

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