Format

Send to

Choose Destination
Cancer Invest. 2016 Sep 13;34(8):393-400. doi: 10.1080/07357907.2016.1217422. Epub 2016 Aug 24.

Combined Expression of c-jun, c-fos, and p53 Improves Estimation of Prognosis in Oral Squamous Cell Carcinoma.

Author information

1
a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
2
b Department of Oral Medicine , Heilongjiang Nursing College , Harbin , China.

Abstract

To identify the prognostic value of c-jun, c-fos, and p53 in oral cancer, we examined the impact of immunohistochemical expression of these markers on tumor progression in 157 oral squamous cell carcinoma (OSCC). We found that c-jun or c-fos was significantly associated with lymph node metastasis, and coexpression of c-jun/c-fos, or c-jun/c-fos/p53 were significantly associated with lymph node metastasis, poor differentiation and clinical stage. The coexpression of c-jun/c-fos/p53 was identified as independent prognostic factors for overall survival. Simultaneous coexpression of these markers in OSCCs might prove to be a useful indicator for differentiation of low and high-risk patients.

KEYWORDS:

Oral squamous cell carcinoma; c-fos; c-jun; p53

PMID:
27558649
DOI:
10.1080/07357907.2016.1217422
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center