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Nat Rev Neurosci. 2016 Oct;17(10):623-35. doi: 10.1038/nrn.2016.92. Epub 2016 Aug 25.

Emerging roles of GluN3-containing NMDA receptors in the CNS.

Author information

1
Cellular Neurobiology and Neurophysiology Laboratory, Center for Applied Medical Research (CIMA) and University of Navarra Medical School, Avda Pio XII 55, 31008 Pamplona, Spain.
2
Instituto de Neurociencias (CSIC-UMH), 03550 San Juan de Alicante, Spain.
3
Allen Institute for Brain Science, Seattle, Washington 98109, USA.

Abstract

GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the 'classical' NMDARs, which are composed solely of GluN1 and GluN2 subunits, and have non-conventional biophysical, trafficking and signalling properties. In the CNS, they seem to have important roles in delaying synapse maturation until the arrival of sensory experience and in targeting non-used synapses for pruning. The reactivation of GluN3A expression at inappropriate ages may underlie maladaptive synaptic rearrangements observed in addiction, neurodegenerative diseases and other major brain disorders. Here, we discuss current evidence for these and other emerging roles for GluN3-NMDARs in the physiology and pathology of the CNS.

PMID:
27558536
DOI:
10.1038/nrn.2016.92
[Indexed for MEDLINE]

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