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Curr Genet. 2017 May;63(2):187-193. doi: 10.1007/s00294-016-0642-y. Epub 2016 Aug 24.

A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions.

Author information

1
URPHYM-GEMO, Namur Research College (NARC), The University of Namur, 5000, Namur, Belgium.
2
Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain.
3
URPHYM-GEMO, Namur Research College (NARC), The University of Namur, 5000, Namur, Belgium. Damien.Hermand@unamur.be.

Abstract

The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.

KEYWORDS:

Chromatin; Mitosis; Nucleosome; RSC; Yeast

PMID:
27558480
PMCID:
PMC5383693
DOI:
10.1007/s00294-016-0642-y
[Indexed for MEDLINE]
Free PMC Article

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