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Sci Rep. 2016 Aug 25;6:31775. doi: 10.1038/srep31775.

Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity.

Author information

1
Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
2
Center for Bioinformatics, Henry Ford Health System, Detroit, MI, 48202, USA.
3
Division of Gastroenterology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
4
Division of Allergy and Clinical Immunology, Department of Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
5
Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
6
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
7
Division of Allergy and Immunology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.

Abstract

The joint impact of pregnancy, environmental, and sociocultural exposures on early life gut microbiome is not yet well-characterized, especially in racially and socioeconomically diverse populations. Gut microbiota of 298 children from a Detroit-based birth cohort were profiled using 16S rRNA sequencing: 130 neonates (median age = 1.2 months) and 168 infants (median age = 6.6 months). Multiple factors were associated with neonatal gut microbiome composition in both single- and multi-factor models, with independent contributions of maternal race-ethnicity, breastfeeding, mode of delivery, marital status, exposure to environmental tobacco smoke, and indoor pets. These findings were consistent in the infants, and networks demonstrating the shared impact of factors on gut microbial composition also showed notable topological similarity between neonates and infants. Further, latent groups defined by these factors explained additional variation, highlighting the importance of combinatorial effects. Our findings also have implications for studies investigating the impact of the early life gut microbiota on disease.

PMID:
27558272
PMCID:
PMC4997337
DOI:
10.1038/srep31775
[Indexed for MEDLINE]
Free PMC Article

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