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Clin Exp Pharmacol Physiol. 2016 Dec;43(12):1243-1246. doi: 10.1111/1440-1681.12655.

Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women.

Author information

1
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA.
2
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
3
Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
4
Department of Human Nutrition and Food Science, Cal Poly Pomona, Pomona, CA, USA.
5
Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), Florida State University, Tallahassee, FL, USA.

Abstract

Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.

KEYWORDS:

aging; aortic haemodynamic responses; appendicular skeletal muscle mass; arterial stiffness; isometric exercise; obesity

PMID:
27558210
DOI:
10.1111/1440-1681.12655
[Indexed for MEDLINE]

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