Format

Send to

Choose Destination
J Biol Rhythms. 2016 Oct;31(5):415-27. doi: 10.1177/0748730416662748. Epub 2016 Aug 23.

Circadian Clocks in Articular Cartilage and Bone: A Compass in the Sea of Matrices.

Author information

1
Faculty of Biology, Medicine and Health, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, UK.
2
Faculty of Biology, Medicine and Health, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, UK qing-jun.meng@manchester.ac.uk.

Abstract

Temporally coordinated resorption and synthesis is the key to maintaining healthy bones. Articular cartilage is a highly specialized connective tissue within the joints that lines the surface of a long bone. Emerging evidence has suggested a critical role of the circadian system in controlling cartilage and bone biology. Articular cartilage is sparsely populated with chondrocytes, surrounded by abundant extracellular matrices that are synthesized and maintained solely by chondrocytes. Once damaged, the articular cartilage tissue has poor capacity for endogenous repair, leaving the joints prone to osteoarthritis, an age-related painful condition that affects millions of individuals worldwide. An important question is how articular cartilage has evolved its remarkable capacity to maintain homeostasis and withstand daily biomechanical challenges associated with resting/activity cycles. Equally important is how this avascular and aneural tissue senses time and uses this information to coordinate daily phases of metabolic activity and tissue remodeling/repair. Bone tissue derived from cartilage has similarly sparse populations of resident cells living in dense and largely mineralized matrices. We discuss recent progress on circadian clocks in these matrix-rich skeletal tissues and highlight avenues for future research.

KEYWORDS:

aging; bone; chondrocyte; circadian clocks; extracellular matrix

PMID:
27558096
DOI:
10.1177/0748730416662748
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center