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Clin Pharmacol Ther. 2017 Mar;101(3):320-323. doi: 10.1002/cpt.458. Epub 2016 Sep 28.

A Molecular Basis for Innovation in Drug Excipients.

Author information

1
Department of Pharmaceutical Chemistry & QB3 Institute, University of California, San Francisco, California, USA.
2
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
3
Food & Drug Administration, Silver Spring, Maryland, USA.

Abstract

Excipients are ubiquitous in drug formulation, ensuring that active ingredient drugs are properly released on dosing, retain their properties over time, and are palatable, among other roles. Despite their crucial roles, surprisingly little is known about their systemic availability and activities on molecular targets. Here we review key excipient properties, introduce a public-accessible database that enumerates and categorizes them, and sketch a strategy for exploring their possible direct actions on molecular targets.

PMID:
27557422
DOI:
10.1002/cpt.458
[Indexed for MEDLINE]

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