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Nutrients. 2016 Aug 22;8(8). pii: E515. doi: 10.3390/nu8080515.

Natural Polyphenols for Prevention and Treatment of Cancer.

Author information

1
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhouyue3@mail2.sysu.edu.cn.
2
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhengj37@mail2.sysu.edu.cn.
3
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. liya28@mail2.sysu.edu.cn.
4
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. xudp@mail2.sysu.edu.cn.
5
School of Chinese Medicine, The University of Hong Kong, Hong Kong, China. u3003781@connect.hku.hk.
6
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. chenyum@mail.sysu.edu.cn.
7
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.
8
South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-sen University, Guangzhou 510006, China. lihuabin@mail.sysu.edu.cn.

Abstract

There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.

KEYWORDS:

anti-inflammation; anticancer; antioxidant; flavonoid; polyphenol

PMID:
27556486
PMCID:
PMC4997428
DOI:
10.3390/nu8080515
[Indexed for MEDLINE]
Free PMC Article

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