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Clin Cardiol. 2016 Sep;39(9):537-43. doi: 10.1002/clc.22563. Epub 2016 Aug 24.

Meta-analysis of Vitamin D Deficiency and Risk of Atrial Fibrillation.

Author information

1
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
2
Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts.
3
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China. liutongdoc@126.com.

Abstract

BACKGROUND:

There are accumulating studies investigating the association between vitamin D status and the risk of atrial fibrillation (AF). However, the results in these studies were inconsistent in regard to the role of vitamin D deficiency in predicting the development of AF.

HYPOTHESIS:

Vitamin D deficiency is associated increased risk of AF.

METHODS:

Using PubMed and Embase databases, we searched for records published before March 2016. Additionally, a manual search was conducted using all review articles on this topic. Of the 587 initially identified records, 8 studies with a total of 27 307 patients were finally analyzed.

RESULTS:

In the categorical variable analysis, vitamin D deficiency was associated with the occurrence of AF (odds ratio: 1.31, 95% confidence interval: 1.06-1.62, P = 0.01). In the continuous variable analysis, higher vitamin D levels appear to protect against the development of AF (odds ratio: 0.92, 95% confidence interval: 0.87-0.97, P = 0.002). However, the association is weak on the pooled analysis of prospective cohort studies focused on new-onset AF (P = 0.07 and 0.04), whereas the pooled analysis of case-control studies mainly assessing for chronic AF strongly support such an association (both P < 0.0001).

CONCLUSIONS:

Vitamin D deficiency modestly increases the risk of AF. Further studies are needed to determine the if there is a direct causal relationship between vitamin D levels and AF and whether vitamin D supplements will prevent new-onset AF.

PMID:
27556176
PMCID:
PMC6490727
DOI:
10.1002/clc.22563
[Indexed for MEDLINE]
Free PMC Article

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